The Anticancer actions of Trifolium pratense (Red Clover) by Joseph J Collins, RN, ND

Trifolium pratense has an isoflavone called biochanin A that has anticancer properties against MCF-7 breast carcinoma cells [1]. Red clover extracts acts like an estrogen antagonist [2], and prevents estradiol from stimulating breast cancer cells, while at the same time decreasing vasomotor symptoms such as hot flashes and night sweats. The plant extracts from red clover decrease cell proliferation and increase apoptosis of various cancer cell lines including cancers of the colon, prostate, breast, cervix, liver, pancreas, stomach and ovaries [3].

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References
To review the PubMed listing of any reference, go to www.ncbi.nlm.nih.gov/PubMed/ and enter the PubMed PMID number at the end of the reference.
[1] Han EH, Kim JY, Jeong HG. Effect of biochanin A on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Arch Pharm Res. 2006 Jul;29(7):570-6. PubMed PMID: 16903077.
[2] Mannella P, Tosi V, Russo E, Zullino S, Pancetti F, Gompal S, Polak K,Genazzani AR, Genazzani AD, Simoncini T. Effects of red clover extracts on breast cancer cell migration and invasion. Gynecol Endocrinol. 2012 Jan;28(1):29-33. doi: 10.3109/09513590.2011.579660. Epub 2011 May 26. PubMed PMID: 21615235.
[3] Reiter E, Gerster P, Jungbauer A. Red clover and soy isoflavones--an in vitro safety assessment. Gynecol Endocrinol. 2011 Dec;27(12):1037-42. doi: 10.3109/09513590.2011.588743. Epub 2011 Aug 1. PubMed PMID: 21801124.